Pope Francis remains in critical condition and “is not out of danger,” the Holy See Press Office announced Saturday evening in Rome.

The 88-year-old pontiff “experienced an asthma-like respiratory crisis of prolonged intensity” Saturday morning that required the administration of high-flow oxygen, according to the Vatican’s medical update.

Blood tests revealed a low platelet count (thrombocytopenia), associated with anemia, which required blood transfusions.

While the Holy Father remains alert and spent the day in an armchair, he is “more uncomfortable than yesterday,” the statement said, describing the prognosis as guarded.

The Vatican confirmed earlier Saturday that the pope will not lead the traditional Sunday Angelus prayer on Feb. 23. During a press conference at Gemelli Hospital on Friday, the medical team caring for the pontiff had described his condition as serious, noting that Pope Francis was fully aware of his situation.

Prayerful presence marked the scene outside Rome’s Gemelli Hospital on Saturday afternoon as religious sisters and faithful gathered to petition for Pope Francis’ recovery through the intercession of the Blessed Virgin Mary.